Autosomal Dominant Polycystic Kidney Disease (ADPKD) Kidney Disease Study

ADPKD Research Study Huntington Park | Valiance Clinical Research
📞 323-484-0508 Huntington Park, CA
Now Enrolling — Huntington Park, CA

KIDNEY DISEASE RESEARCH STUDY

If you have been diagnosed with ADPKD, you may qualify for a clinical research study offering no-cost care and compensation.

Do You Qualify?

✓ Ages 18–55
✓ Diagnosed with ADPKD
✓ Kidney function within certain range (eGFR 30–89)
✓ Not currently taking tolvaptan

You May Not Qualify If You:

  • ✗Have diabetes
  • ✗Have had a kidney transplant or are on dialysis
  • ✗Are pregnant or planning to become pregnant
  • ✗Have certain active infections (HIV, Hepatitis B or C)

What's Involved

  • Study lasts approximately 2 years
  • IV infusion every 4 weeks at the study site
  • Some visits may be done from home (decentralized option)
  • MRI scans at certain visits
  • Regular lab work and check-ins

What You Get

  • $50–$250 compensation per visit
  • Free transportation to and from the study site
  • Study medication at no cost
  • Regular health monitoring at no charge
Important: Participation is voluntary. You may withdraw at any time without penalty or loss of benefits you are otherwise entitled to.
Fill Out the Form Below to See If You Qualify ↓

About This Study

Key details about the ADPKD research study

Study Purpose
Advancing ADPKD Treatment

This clinical trial investigates a new investigational medication for adults living with Autosomal Dominant Polycystic Kidney Disease (ADPKD), aiming to slow kidney function decline and improve outcomes.

Study Duration
Approximately 2 Years

Participants receive IV infusions every 4 weeks at our Huntington Park facility, with some visits available from home. Regular monitoring ensures safety and tracks treatment progress.

Location
Huntington Park, California

All in-person study visits take place at our research facility in Huntington Park, CA. Free parking and complimentary transportation are available.

Who Can Join
Adults 18–55 with ADPKD

Adults ages 18 to 55 diagnosed with ADPKD with kidney function (eGFR) between 30–89 and not currently on tolvaptan may be eligible. Additional criteria apply.

Understanding ADPKD

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder characterized by the growth of numerous cysts in the kidneys. Over time, these cysts can cause the kidneys to enlarge and lose function, potentially leading to kidney failure.

ADPKD is one of the most common inherited kidney disorders, affecting approximately 1 in 400 to 1 in 1,000 people worldwide. The condition is progressive, meaning kidney function typically declines over time, often requiring dialysis or kidney transplant in advanced stages.

Clinical trials like this one are essential to finding new treatments that can slow disease progression, preserve kidney function longer, and improve quality of life for people living with ADPKD.

What Causes ADPKD?

ADPKD is caused by mutations in either the PKD1 or PKD2 gene. It's called "autosomal dominant" because inheriting just one mutated gene from either parent is enough to cause the disease.

Common Symptoms

Symptoms may include high blood pressure, back or side pain, blood in urine, frequent kidney infections, and kidney stones. Some people have no symptoms until kidney function significantly declines.

Why Clinical Trials Matter

Current treatment options for ADPKD are limited. Research is advancing new therapies that may better slow cyst growth, preserve kidney function, and delay or prevent the need for dialysis or transplant.

Participant Benefits

Everything you receive as a study participant — at no cost to you

$

$50–$250 Per Visit

Receive compensation for your time and travel at each completed study visit, recognizing the value of your participation in advancing ADPKD research.

🚗

Free Transportation

Complimentary transportation to and from our Huntington Park research site for all scheduled in-person visits. Free parking is also available on-site.

💊

Study Medication at No Cost

All investigational medication and study-related medical care — including IV infusions, labs, and MRIs — are provided completely free of charge.

🩺

Regular Health Monitoring

Comprehensive kidney health monitoring including regular lab work, imaging, and assessments by our dedicated nephrology research team.

🏠

Decentralized Visit Options

Some study visits may be completed from the comfort of your home, reducing travel burden while maintaining high-quality care and monitoring.

🔬

Advance ADPKD Research

Help develop new treatments that could slow disease progression and improve outcomes for people living with ADPKD worldwide.

Full Eligibility Criteria

You may be eligible to participate if you meet the following criteria. Final eligibility is confirmed at your screening visit.

  • ✓ Ages 18 to 55 years old
  • ✓ Diagnosed with ADPKD (Autosomal Dominant Polycystic Kidney Disease)
  • ✓ Kidney function (eGFR) between 30–89 mL/min/1.73 m²
  • ✓ Not currently taking tolvaptan or stopped at least 30 days prior
  • ✓ Able to attend in-person visits in Huntington Park, CA
  • ✓ Willing to use effective contraception (if applicable)

Not sure if you qualify? Our study team is happy to answer your questions and help determine if this study is right for you.

What to Expect

A step-by-step look at the study journey from sign-up to completion

1

Sign Up & Phone Screening

Submit your information and our study coordinator will reach out within 1–2 business days.

  • Brief phone call to review basic eligibility (5–10 minutes)
  • Answer questions about your ADPKD diagnosis and current health
  • Discuss kidney function and any current medications
  • Ask any questions you have about the study
2

In-Person Screening Visit

If eligible by phone, you'll visit our Huntington Park facility for a comprehensive evaluation.

  • Meet the nephrology research team and tour the facility
  • Review the informed consent document thoroughly
  • Physical examination and medical history review
  • Kidney function tests and comprehensive lab work
  • Baseline MRI scan (if not recently completed)
  • Confirm final eligibility for enrollment
3

Enrollment & First Treatment

If you qualify and choose to enroll, you'll begin study treatment.

  • Sign informed consent after all your questions are answered
  • Receive your full study schedule and participant materials
  • First IV infusion administered at the study site
  • Training on any home-based monitoring or visits
  • Get 24/7 contact information for the study team
4

Ongoing Study Participation

Attend regular visits over approximately 2 years for treatment and monitoring.

  • IV infusion every 4 weeks at the Huntington Park site
  • Some check-in visits may be completed from home
  • Regular lab work to monitor kidney function and safety
  • Periodic MRI scans to assess kidney size and cyst growth
  • Compensation issued at each completed visit
  • Report any health changes or symptoms to the study team
5

Study Completion

Complete your final visit and receive a summary of your health data and next steps.

  • Final kidney function assessment and MRI
  • Discussion of findings with the study nephrologist
  • Guidance on continued ADPKD care and management
  • Receive your final visit compensation

Frequently Asked Questions

Answers to common questions about the study and ADPKD

What is a clinical trial?+
A clinical trial is a research study that evaluates the safety and effectiveness of new medical treatments. All clinical trials follow strict scientific and ethical standards and are overseen by independent review boards to protect participants. They are essential for developing better therapies for serious conditions like ADPKD.
Why should I consider participating?+
Participating gives you access to a potentially promising new treatment at no cost, along with close monitoring from a dedicated nephrology team. You'll receive compensation for your time, free transportation, and have the opportunity to contribute to research that may benefit others living with ADPKD. Many participants report feeling well-supported throughout the study.
Is participating in a clinical trial safe?+
Yes. Participant safety is the top priority. This study is conducted under strict protocols approved by an Institutional Review Board (IRB) and follows FDA and Good Clinical Practice (GCP) guidelines. You'll be closely monitored throughout, have access to the study team 24/7, and can withdraw at any time for any reason without penalty.
What exactly is ADPKD?+
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder that causes numerous cysts to develop in the kidneys. These fluid-filled sacs can grow and multiply over time, causing the kidneys to enlarge and lose function. ADPKD is progressive and can eventually lead to kidney failure requiring dialysis or transplant.
Is ADPKD hereditary?+
Yes. ADPKD is inherited in an autosomal dominant pattern, meaning you only need to inherit one mutated gene from one parent to develop the disease. If one parent has ADPKD, each child has a 50% chance of inheriting it. However, about 10% of cases occur from new genetic mutations with no family history.
What is eGFR and why does it matter?+
eGFR (estimated Glomerular Filtration Rate) is a measure of how well your kidneys are filtering waste from your blood. It's calculated from a blood test and reported as mL/min/1.73 m². Normal eGFR is above 90. This study requires eGFR between 30–89, representing moderate kidney disease where treatment may be most beneficial in slowing progression.
What is an IV infusion and how long does it take?+
An IV (intravenous) infusion is when medication is delivered directly into a vein through a small tube. The study medication is given this way every 4 weeks. The infusion itself typically takes 1-2 hours, and you'll be monitored before and after to ensure your safety and comfort.
What are decentralized visits?+
Some study visits can be completed from your home instead of coming to the research site. This might include telehealth check-ins with the study team, at-home blood pressure monitoring, or having a mobile nurse visit you for blood draws. IV infusions must be done at the study site, but these remote options reduce travel burden.
How often will I need MRI scans?+
MRI scans are performed at specific timepoints during the study to measure kidney size and cyst volume. The exact schedule will be explained in detail during your screening visit. All MRI scans are provided at no cost as part of the study.
What is tolvaptan and why can't I be taking it?+
Tolvaptan (brand name Jynarque) is currently the only FDA-approved medication specifically for slowing ADPKD progression. This study is testing a different investigational treatment, so participants cannot be on tolvaptan during the trial. If you've stopped tolvaptan recently, there's a 30-day washout period before you can enroll.
Why is there an age limit of 55?+
The age range of 18–55 represents the population where ADPKD progression is most active and where interventions may have the greatest impact on long-term outcomes. This is the target population for this particular study protocol.
Can I participate if I have high blood pressure?+
High blood pressure is very common in people with ADPKD and does not automatically disqualify you. As long as your blood pressure is reasonably controlled with medication, you may still be eligible. The screening team will review your specific situation.
Can I leave the study if I change my mind?+
Yes. Participation is entirely voluntary. You have the right to withdraw at any time, for any reason, without penalty or loss of any benefits you are otherwise entitled to. Simply notify the study team if you wish to discontinue. We may request an optional final safety visit to ensure your kidney health is stable.
Will my personal and medical information stay confidential?+
Yes. Your information is fully protected under HIPAA regulations. Your personal identity will never appear in any study publications or reports. All research data is de-identified, meaning it cannot be traced back to you as an individual. Only authorized study staff have access to your identifiable records, and all data is stored securely.
What if I experience side effects?+
You should report any new or worsening symptoms to the study team immediately. You'll have 24/7 access to the study physician. All side effects are carefully tracked and managed. If you experience serious side effects, your participation may be paused or stopped to ensure your safety, and you'll receive appropriate medical care.

Ready to See If You Qualify?

Sign up today or call us to learn more. Our team will review your information and reach out within 1–2 business days.

Sign Up Now 📞 Call 323-484-0508
Huntington Park Location
323-484-0508
Email
contact@valianceclinicalresearch.com

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