About This Study

Key details about the NASH/MASH liver disease research study

Study Purpose

Advancing NASH/MASH Treatment

This clinical trial investigates new approaches to treating liver disease caused by nonalcoholic steatohepatitis (NASH) or metabolic-associated steatohepatitis (MASH) in adults with compensated cirrhosis.

Location

Tarzana, California

All study visits take place at our state-of-the-art research facility in Tarzana, CA. Free parking is available, and complimentary transportation to and from the site is provided.

Study Status

Now Enrolling

We are actively enrolling qualified participants. Our team is reviewing applications and conducting screenings on an ongoing basis. Spots are limited — apply today.

Who Can Join

Adults 18+ with NASH/MASH Cirrhosis

Adults 18 years and older who have been diagnosed with compensated cirrhosis related to NASH or MASH may be eligible. Final eligibility is determined at screening.

Understanding NASH & MASH

Nonalcoholic steatohepatitis (NASH) and metabolic-associated steatohepatitis (MASH) are serious forms of fatty liver disease in which fat accumulation in the liver causes inflammation and cell damage over time.

Without treatment, NASH/MASH can progress to cirrhosis — scarring of the liver — which affects the liver's ability to function normally. "Compensated cirrhosis" means the liver is scarred but still able to perform most of its functions.

Clinical trials like this one are critical to finding new therapies that can slow or reverse liver damage and improve long-term outcomes for people living with this condition.

What is NASH?

Nonalcoholic steatohepatitis — liver inflammation and damage caused by fat buildup, not alcohol. It is a more severe form of nonalcoholic fatty liver disease (NAFLD).

What is MASH?

Metabolic-associated steatohepatitis — a newer term for the same condition that emphasizes its link to metabolic risk factors such as obesity, type 2 diabetes, and high blood pressure.

What is Compensated Cirrhosis?

An early stage of cirrhosis where the liver is scarred but still able to function. Symptoms may be mild or absent, making early intervention especially impactful.

Participant Benefits

Everything you receive as a study participant — at no cost to you

$

$50–$250 Per Visit

Receive compensation for your time and travel at each completed study visit, recognizing the value of your participation in advancing liver disease research.

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Free Transportation

Complimentary transportation to and from our Tarzana, CA research site for all scheduled visits. Free parking is also available on-site.

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No-Cost Study Care

All study-related medication, lab work, exams, and medical care are provided at absolutely no cost to you throughout the entire trial.

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Liver Health Monitoring

Regular liver function assessments, lab tests, and comprehensive medical monitoring by our dedicated research team throughout your participation.

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Expert Medical Team

Access to experienced hepatology research physicians and study coordinators who are focused on your safety and health outcomes.

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Advance Liver Research

Help develop new treatments that could improve outcomes for millions of people living with NASH and MASH worldwide.

Do You Qualify?

You may be eligible to participate if you meet the following general criteria. Final eligibility is confirmed during your screening visit.

• ✓ 18 years of age or older
• ✓ Diagnosed with compensated cirrhosis related to NASH (nonalcoholic steatohepatitis) or MASH (metabolic-associated steatohepatitis)
• ✓ Living with NASH or MASH as confirmed by a healthcare provider
• ✓ Able to attend study visits at our Tarzana, CA facility

Not sure if you qualify? Our team is happy to answer your questions. Call us or click below to get started — it only takes a few minutes.

Sign Up to Learn More 📞 Call 818-938-9167

What to Expect

A step-by-step look at the study journey from sign-up to completion

1

Sign Up & Phone Screening

Submit your information and our study coordinator will reach out within 1–2 business days.

• Brief phone call to review basic eligibility (5–10 minutes)
• Answer questions about your diagnosis and health history
• Ask any questions you have about the study

2

In-Person Screening Visit

If eligible by phone, you'll be invited to our Tarzana facility for a full evaluation.

• Meet the research team and tour the facility
• Review the informed consent document and ask questions
• Complete medical history and physical examination
• Liver function tests and laboratory work
• Confirm final eligibility for enrollment

3

Enrollment & Consent

If you qualify and choose to enroll, you'll officially become a study participant.

• Sign informed consent after all your questions are answered
• Receive your full study schedule and participant materials
• Get 24/7 contact information for the study team

4

Study Participation & Visits

Attend regular scheduled visits for monitoring and study treatment.

• Receive study medication as part of your treatment schedule
• Regular liver function tests and health assessments
• Compensation issued at each completed visit
• Report any health changes to the study team
• Free transportation available for every visit

5

Study Completion

Complete your final visit and receive a summary of your health data and next steps.

• Final liver health assessment and evaluation
• Discussion of findings with the study physician
• Recommendations for continued care
• Receive your final compensation

Frequently Asked Questions

Answers to common questions about the study and liver disease

All Questions General About NASH/MASH About This Study Eligibility Compensation Safety & Rights

What is a clinical trial?+

A clinical trial is a research study that evaluates the safety and effectiveness of new medical treatments. All clinical trials follow strict scientific and ethical standards and are overseen by independent review boards to protect participants. They are essential for developing new treatments and improving care for patients with serious conditions like liver disease.

Why should I consider participating?+

Participating gives you access to potentially promising new treatments at no cost, along with close monitoring from a dedicated medical team. You'll also receive compensation for your time and contribute to research that could benefit many others living with NASH and MASH. Many participants find the experience personally meaningful and report feeling well-supported throughout the process.

Is it safe to participate in a clinical trial?+

Yes. All clinical trials are designed with participant safety as the top priority. This study follows strict protocols approved by an Institutional Review Board (IRB). You'll be closely monitored throughout, have 24/7 access to the study medical team, and can withdraw at any time for any reason without penalty.

What is the difference between NASH and MASH?+

NASH (nonalcoholic steatohepatitis) and MASH (metabolic-associated steatohepatitis) refer to the same underlying liver condition. MASH is a newer, more precise term that reflects the strong link between the condition and metabolic risk factors such as obesity, type 2 diabetes, and high blood pressure. Both terms describe liver inflammation and damage caused by fat buildup, unrelated to alcohol use.

What does "compensated cirrhosis" mean?+

Compensated cirrhosis means the liver has significant scarring (fibrosis) but is still able to carry out most of its normal functions. At this stage, many people have few or no symptoms. It differs from decompensated cirrhosis, where the liver can no longer keep up with the body's demands and complications such as fluid buildup or internal bleeding occur. Early treatment in the compensated stage can be critical to preventing progression.

Can NASH/MASH cirrhosis be treated?+

While there are currently limited approved therapies for NASH/MASH cirrhosis, research is advancing rapidly. Lifestyle changes, management of metabolic risk factors, and emerging treatments are showing promise. Clinical trials like this one are at the forefront of identifying effective therapies that can slow, halt, or potentially reverse liver damage in people with this condition.

What does participation in this study involve?+

Participation involves regular visits to our Tarzana facility for study treatment, liver function monitoring, and health assessments. You'll receive study medication as part of the protocol, and all care related to the study is provided at no cost to you. The study team will walk you through the full schedule and what to expect at each visit before you make any commitment.

Can I keep seeing my regular doctor during the study?+

Absolutely. We encourage you to maintain your relationship with your primary care physician, gastroenterologist, or hepatologist. With your permission, we will coordinate with your existing healthcare providers to ensure continuity of care. It's important to keep all your doctors informed of any changes in your health or medications.

Where does the study take place?+

All study visits are conducted at our research facility in Tarzana, California. The site is equipped with modern medical technology and staffed by a dedicated research team. Free parking is available on-site, and complimentary transportation is provided for all participants who need it.

I was diagnosed with NASH years ago. Can I still participate?+

Yes, the timing of your diagnosis does not necessarily disqualify you. What matters most is your current diagnosis and health status, particularly whether you have been confirmed to have compensated cirrhosis related to NASH or MASH. Our study team will review your medical history during the screening process to determine eligibility.

What if I have other conditions like diabetes or high blood pressure?+

Having other conditions does not automatically disqualify you. In fact, metabolic conditions like type 2 diabetes and hypertension are very common in people with NASH/MASH. Our medical team will conduct a full review of your health history during the screening visit to determine if the study is appropriate for you.

Do I need a referral from my doctor to join?+

No referral is required to express interest or begin the screening process. However, we will want to review your medical records related to your NASH/MASH diagnosis, so having your prior test results, biopsy reports, or imaging studies available will be helpful when you speak with our study coordinator.

How much will I be compensated?+

Participants receive between $50 and $250 per completed study visit. The amount varies depending on the type and length of the visit. Visits that involve more procedures or take more of your time are compensated at a higher rate. You will be provided a complete compensation schedule before enrolling.

How does the free transportation work?+

We provide complimentary transportation to and from our Tarzana facility for all scheduled study visits. When you schedule each appointment, simply let our team know you need transportation and we will coordinate the details. Free on-site parking is also available if you prefer to drive.

What if I need to reschedule or miss a visit?+

We understand that life happens. If you need to reschedule, please contact our study coordinator as early as possible. Missed or rescheduled visits will not result in immediate removal from the study, but consistent attendance is important for your safety and the integrity of the research. Compensation is only provided for completed visits.

Can I leave the study if I change my mind?+

Yes. Participation is completely voluntary. You have the right to withdraw at any time, for any reason, without penalty or loss of any benefits you are otherwise entitled to. Simply notify the study team if you wish to discontinue. We may request a final safety visit, but this is optional.

Will my personal and medical information stay confidential?+

Yes. Your information is fully protected under HIPAA regulations. Your personal identity will never appear in any study publications or reports. All research data is de-identified, meaning it cannot be traced back to you as an individual. Only authorized study staff have access to your identifiable records, and all data is stored securely.

Who oversees the study to protect participants?+

This study is reviewed and monitored by an Institutional Review Board (IRB), an independent committee of medical professionals and community members whose role is to safeguard participant rights and well-being. The study also follows FDA regulations and Good Clinical Practice (GCP) guidelines.

What is the Informed Consent process?+

Before enrolling, you will receive a detailed Informed Consent document explaining the study's purpose, procedures, potential risks and benefits, and your rights. You will have ample time to review it, discuss it with family or your own physician if you wish, and ask the study team any questions. Signing the consent form means you agree to participate, but you may still withdraw at any time after signing.

Ready to See If You Qualify?

Sign up today or call us directly. Our team will review your information and reach out within 1–2 business days.

Sign Up Now 📞 Call 818-938-9167

Phone

818-938-9167

Email

VCRTarzana@valianceclinicalresearch.com

Location

Tarzana, California

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